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21 Jan 2016 Recently, the Spanish Myeloma Group conducted a phase III study (QUIREDEX) in which high risk SMM patients were randomly assigned either to true MRD in conventionally defined CR patients in order to adopt new CR definitions that will guide our therapeutic strategies toward MM cure [47] ; [49] .
25 Mar 2011 Indeed, both MGUS and SMM represent the quintessential model for studying multiple myeloma precursor disease, and to develop early intervention QUIREDEX: revlimid (lenalidomide) and dexamethasone (ReDex) treatment versus observation in patients with smoldering multiple myeloma with high
15 Jun 2014 RESULTS FROM IRON (INTERLABORATORY ROBUSTNESS OF NEXT-GENERATION SEQUENCING) II STUDY, Brugnoletti Fulvia Ri, Received .. LONGITUDINAL IMMUNOPHENOTYPIC PROFILING OF IMMUNE EFFECTOR CELLS FROM THE QUIREDEX TRIAL, Paiva Bruno Cristina, Received.
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19 May 2017 into improved clinical outcomes, and a new study, iStopMM, is underway to ascertain the benefit of population- such as FLC analysis can be used to guide the use of more invasive procedures for detection of minimal residual disease is the subject .. high-risk smouldering multiple myeloma (QuiRedex):.
21 Jun 2007 We searched a computerized database and reviewed the medical records of all patients at Mayo Clinic who fulfilled the criteria of the International Myeloma Working Group for the diagnosis of smoldering multiple myeloma between 1970 and 1995. Bone marrow aspirate and biopsy specimens were studied
1 Aug 2013 For patients with smoldering multiple myeloma, the standard of care is observation until symptoms develop. In this randomized, open-label, phase 3 trial, we randomly assigned 119 patients with high-risk smoldering myeloma to treatment or observation. Early treatment for patients
Abstract: From October 1983 until December 1988, 50 patients with asymptomatic multiple myeloma stage I were included in a prospective randomized multi-centre study comparing melphalan-prednisone (MP) therapy started at the time of diagnosis with deferred therapy where MP was started at the time of disease
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19 Jul 2016 taking part in the phase 3 QuiRedex study, which reported in 2013 that the early treatment of high-risk smoldering myeloma with lenalidomide (Revlimid, Celgene Corporation) and dexamethasone (multiple brands) was associated with significantly high response rates (N Engl J Med. 2013;369:438-447).
     

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